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2014-06-03 神经生物学前沿学术报告系列 Xiaoqin Wang

报告题目: Marmoset as a model system for studying the neural basis of audition and social interactions

 

报告人: Xiaoqin Wang, Ph.D.

 

Professor of Biomedical Engineering and Neuroscience

Department of Biomedical Engineering

Johns Hopkins University School of Medicine

Director of Tsinghua-Johns Hopkins Joint Center for Biomedical Engineering Research

时间:   2014年6月4日(周三),下午:14:30-16:00

地点:   西区生物楼329会议室

主办单位:中国科学技术大学生命科学学院

中国科学院脑功能与脑疾病重点实验室

 

报告简介: Properly chosen animal models are pivotal in understanding brain mechanisms for behaviors. Research on the primate auditory system has been hampered for the lack of appropriate animal models with adequate vocal behaviors in laboratory conditions. We have developed a new model system to study neural basis of audition and vocal communication using the common marmoset (Callithrix jacchus), a highly vocal New World primate species. Marmosets have a rich repertoire of communication calls and remain highly vocal in captivity. Anatomically, marmosets have a smooth brain that provides easy access to many regions of the cerebral cortex for electrophysiological and optical recordings. They are easily bred and have a high reproductive rate, making it feasible to conduct developmental and transgenic studies. Using this unique model system, we have identified non-linear transformations of time-varying signals in auditory cortex and revealed harmonic organizations of this cortical region. We also showed that cortical representations of self-produced vocalizations are shaped by auditory feedback and vocal control signals during vocal communication. These findings have important implications for understanding how the brain processes speech and music and how it operates during speaking. They also demonstrate the potential of this non-human primate species in studying the neural basis of social interactions.

 

报告人简介: Dr. Xiaoqin Wang received B.S. degree in electrical engineering from Sichuan University (China) and M.S.E. degree in electrical engineering and computer science from University of Michigan. Dr. Wang began his study of the auditory system while pursuing his Ph.D. degree in biomedical engineering at The Johns Hopkins University. After completing his postdoctoral training in somatosensory and auditory cortical neurophysiology at University of California, San Francisco, Dr. Wang joined the faculty of Biomedical Engineering Department of The Johns Hopkins University in 1995 and is currently Professor of Biomedical Engineering, Neuroscience and Otolaryngology. Dr. Wang is also the director of Tsinghua-Johns Hopkins Joint Center for Biomedical Engineering Research. Dr. Wang received a U.S. Presidential Early Career Award for Scientists and Engineers (PECASE) in 1999 and was awarded a ChangJiang Scholar in 2007 by the Ministry of Education in China.

Dr. Wang’s research is in the areas of auditory neuroscience and neural engineering. His work has focused on the understanding of the structure and functions of the auditory cortex and the neural basis of vocal communication. His laboratory has developed a unique experimental model to study these questions, using a highly vocal New World primate, the common marmoset (Callithrix jacchus). Using this model system, his laboratory has systematically studied neural coding properties of the auditory cortex in awake and behaving conditions and revealed specialized cortical representations of complex sound features such as pitch and harmonicity. Dr. Wang’s laboratory has also discovered neural mechanisms involved in vocal feedback control and self-monitoring during speaking. Using newly developed cochlear implant and wireless neural recording techniques in freely roaming marmosets, Dr. Wang’s laboratory is currently studying neural mechanisms underlying cortical processing of vocal communication signals in both normal and hearing-impaired conditions.

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